Evaluating Risks of Insertional Mutagenesis by DNA Transposons in Gene Therapy

Posted on by immusoft

Investigational therapy can be successfully undertaken using viral- and nonviralmediated ex vivo gene transfer. Indeed, recent clinical trials have established the potential for genetically modified T cells to improve and restore health. Recently, the Sleeping Beauty (SB) transposon/transposase system has been applied in clinical trials to stably insert a chimeric antigen receptor (CAR) to redirect T-cell specificity…