Manufacture of T Cells Using the Sleeping Beauty System to Enforce Expression of a CD19-Specific Chimeric Antigen Receptor

Posted on by immusoft

T cells can be reprogrammed to redirect specificity to tumor-associated antigens (TAAs) through the enforced expression of chimeric antigen receptors (CARs). The prototypical CAR is a single-chain molecule that docks with TAA expressed on the cell surface and, in contrast to the T-cell receptor complex, recognizes target cells independent of human leukocyte antigen…